Most of the molecular mechanisms by which cells and organisms respond to the external/extracellular environment and maintain their normal functions have not been elucidated. In addition, “diseases” can be interpreted as conditions caused by the abnormal state of these mechanism.
Hence, we are conducting not only basic research to elucidate the molecular mechanisms that respond to the external/extracellular environment at the cell and in vivo animals, but also collaboration with medical doctors and researchers in company in order to develop new therapeutic agents.
The cells are separated inside and outside by the cell membrane, which causes various changes in response to physical, chemical, heat, nutrition, hormones and other extracellular stimuli. Also at the individual level Molecular mechanisms that maintain in vivo homeostasis in response to external environmental changes are functioning, and these failures are thought to cause various diseases.
Our research group focuses on endoplasmic reticulum membrane ion channels, cell membrane receptors, etc., and aims to elucidate the molecular mechanisms by which cells and individuals respond to the environment.